The information on this section of the website about treatment with Saxenda® (liraglutide injection 3mg) for weight loss in addition to diet and exercise is intended for UK healthcare professionals. If you are a member of the public or a patient, please visit the relevant section:

How Saxenda® (liraglutide injection 3mg) works

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Saxenda® is a once-daily glucagon-like peptide-1 (GLP-1) analogue indicated as an adjunct to a reduced calorie diet and increased physical activity for weight management in adult patients with an initial body mass index of:1

  • ≥30 kg/m2 (obese)
  • ≥27 kg/m2 to <30 kg/m2 (overweight) in the presence of at least one weight-related comorbidity such as dysglycaemia (prediabetes or type 2 diabetes), hypertension, dyslipidaemia, or obstructive sleep apnoea.

Saxenda® should be discontinued after 12 weeks on the 3.0 mg/day dose if patients have not lost at least 5% of their initial body weight.1

The exact mechanism of action is not entirely clear. GLP-1 is a physiological regulator of appetite and food intake. Similar to native GLP-1, Saxenda® works in the braina to decrease appetite and thereby reduce food intake.1

Saxenda® (liraglutide) pack with pen

Saxenda® Mechanism of Action (MoA)

The exact mechanism of action is not entirely clear. Obesity is impacted by hormones and may be hormonally treated.1 Similar to native GLP-1, Saxenda® works in the braina to decrease appetite and thereby reduce food intake.1

Diagram explaining how Saxenda® (liraglutide) works

aShown in animal models.

References

  1. Saxenda® Summary of Product Characteristics.
  2. Orskov C, Wettergren A, Holst JJ. Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day. Scand J Gastroenterol. 1996;31(7):665-670.
  3. Flint A, Raben A, Astrup A, Holst JJ. Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J Clin Invest. 1998;101(3):515-520.
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